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The Pathway for Oxygen
Structure and Function in the Mammalian Respiratory System
Ewald R. Weibel, M.D.
Harvard University Press, 1984

It is rare indeed for one book to be both a first-rate classroom text and a major contribution to scholarship. The Pathway for Oxygen is such a book, offering a new approach to respiratory physiology and morphology that quantitatively links the two. Professionalism in science has led to a compartmentalization of biology. Function is the domain of the physiologist, structure that of the morphologist, and they often operate with vastly disparate concepts and procedures. Yet the performance of the respiratory system depends both on structural and on functional properties that cannot be separated.

The first chapter of The Pathway for Oxygen engages the student with the design and function of the vertebrate respiratory organs from a comparative viewpoint. The second chapter adds to that foundation the link between cell energetics and oxygen needs of the whole animal. With Chapter 3 the excitement begins—new ideas, fresh attacks on old problems, and a fuller account of the power of the quantitative approach Dr. Ewald Weibel has pioneered.

The Pathway for Oxygen will be read eagerly by medical students, graduate students, advanced undergraduates in zoology—and by their professors.

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Symmorphosis
On Form and Function in Shaping Life
Ewald R. Weibel M.D.
Harvard University Press, 2000

This book addresses a simple question: Are animals designed economically? The pronghorn can run at speeds of up to 60 kilometers an hour and can maintain this speed for nearly a full hour. Clearly, the form of this elegant animal is beautifully matched to the function it needs to perform.

This is symmorphosis. The theory of symmorphosis predicts that the size of the parts in a system must be matched to the overall functional demand. Moreover, it predicts that animals must provide their complex systems with a functional capacity that can cope with the highest expected functional demands, possibly including some safety margin to prevent the system from failing when it is overloaded. In Symmorphosis, Ewald Weibel tests these predictions by working out the quantitative relations between form and function.

Physiologists will value this book because Weibel shows them that morphological information can be as quantitative as physiological data. Anatomists will value the book for its demonstration that advanced integrative physiology crucially depends on adequate but rigorously quantitative and testable information on structural design. Finally, anyone interested in the origins of the diverse forms of animals will be fascinated by Weibel's demonstrations that show how animals as different as shrews, pronghorns, dogs, goats--even humans--all develop from essentially the same blueprint by variation of design. This is a hidden beauty of the animal kingdom, which can be uncovered by a rigorous investigation of the quantitative relations of form and function.

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